منابع مشابه
Molecule of the month, PDE4DIP
The gene product, phosphodiesterase 4D (PDE4D) is anchored at the centrosome-Golgi cell region by phosphodiesterase 4D interacting protein (PDE4DIP). PDE4D is a member of a family of phosphohydrolyases. These enzymes are involved in signal transduction and hydrolyze 3' cyclic phosphate bonds in 3’, 5’cGMP and 3’,5’-cAMP to energyze several reactions in the cell. The latter are termed second mes...
متن کاملNRF2 molecule of the month
NRF2 – nuclear factor erythroid 2-related factor 2 is also known as GA binding protein transcription factor, alpha subunit 60kDaGABPA [1, 2]. A recent literature review suggests that NRF2 has complex regulatory roles in cancer. NRF2 is a transcription factor and is upregulated by oncogenes. NRF2 is an antioxidant master regulator and for example, binds to ARE –antioxidant response element. NFR2...
متن کاملDementia and molecule of the month APP
The progressive and relentless accumulation of amyloid beta (Abeta) protein in the brain is a key component of memory loss and dementia in Alzheimer’s disease. This process also occurs and is considered a component of aging, HIV dementia, and other dementias. Abeta is processed from Amyloid precursor protein, APP. Under conditions still under investigation, anomalous Abeta protein fragments are...
متن کاملMolecule of the month: miRNA and Down's syndrome
The pathogenesis and molecular biology of Down’s syndrome are under intense study and advances have been made in the care of patients with Down’s syndrome. Patients with Down’s syndrome may exhibit cognitive impairment and developmental cognitive disorder; post-mortem brain tissue from patients who were older than 40 years may show senile plaques and neurofibrillary tangles as found in Alzheime...
متن کاملMolecule of the month: miRNA and Human Prion brain disease
Human prion brain disease has been studied intensely since 1920. Examples of such diseases include Creutzfeldt-Jakob disease (CJD), fatal familial insomnia, Gerstmann-StrausslerScheinker disease, and Kuru. Central in the epidemiology and pathogenesis of prion diseases is the prion protein itself and the gene for this protein resides on chromosome 12, at locus 20pterp12. The prion protein is ter...
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ژورنال
عنوان ژورنال: Bioinformation
سال: 2012
ISSN: 0973-8894,0973-2063
DOI: 10.6026/97320630008740